Thought Experiment #1
PRDM9 micro-satellites involved with human diversity by modulating the hotspots on the DNA. The PRDM (Positive Regulatory Domain Modulator) gene encodes for a protein which is a Zinc Finger transcriptor and this resides within the nucleus to modulate transcription into the DNA of the cell and modulate the proliferation of the cell with the variance to encode diversity – genetic for propagation and cellular to withstand stressors.
|PRDM 16 on Chromosome 1|
Interesting that PRDM16 is involved in a similar pathway but one of the known issues with PRDM16 is that in a t(1:3) (p36-q21) a subsets of MDS (Myelodysplastic Syndrome) and AML (Acute Myeloid Leukemia) cases have been identified.
Further viral infections lead to over-expression of the PRDM16 gene.
Question: DO sometimes clustering of Acute Leukemia cases represent a viral infection and the subsequent translocations through the PRDM genetic gateway?
Reference: Nature Genetics September 2010.
Just so we are clear, there are PRDMs protein that range from 1-16. 8,12,13 for instance and some are involved in neurogenesis both in the brain and the spinal cord also.
Again adding the thought experiment to this subset, consider during the fetal developmental state, or embryogenesis, over expressions can create some functional changes with the brain development too or maybe not. But that is for another day.
Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis. Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, et al. 2008 Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis. PLoS ONE 3(12): e3859. doi:10.1371/journal.pone.0003859
PRDM activity in the Neural Crest (above) and the Spinal Cord (to the right)